Modified Measles
نویسندگان
چکیده
A 35-year-old man, who received a measles vaccination at 2 years of age, developed a 38.5°C fever 2 days after displaying catarrhal symptoms, and milia-like papules of approximately 1-mm in size extending from the face to the trunk and extremities. However, no fused papules were found (Picture 1-3). Koplik’s spot was not observed in the oral mucosa. The EIA method, revealed that the patient’s measles-IgM antibody titer was 1:9.26, and his measles-IgG antibody titer was 1:128 or lower. A measles RT-PCR showed the presence of measles RNA in throat swab specimens, the further sequencing of the PCR products revealed the measles B3 genotype. We therefore diagnosed the patient with modified measles. Modified measles is difficult to diagnose because of the absence of typical symptoms during outbreaks (1); however, measles is highly infectious, and should be rapidly diagnosed.
منابع مشابه
Modelling measles re-emergence as a result of waning of immunity in vaccinated populations.
An age-structured mathematical model of measles transmission in a vaccinated population is used to simulate the shift from a population whose immunity is derived from natural infection to a population whose immunity is vaccine-induced. The model incorporates waning of immunity in a population of vaccinees that eventually will become susceptible to a milder form of vaccine-modified measles with ...
متن کاملA Recombinant Measles Vaccine with Enhanced Resistance to Passive Immunity
Current measles vaccines suffer from poor effectiveness in young infants due primarily to the inhibitory effect of residual maternal immunity on vaccine responses. The development of a measles vaccine that resists such passive immunity would strongly contribute to the stalled effort toward measles eradication. In this concise communication, we show that a measles virus (MV) with enhanced hemagg...
متن کاملEvaluation of an expanded case definition for vaccine-modified measles in a school outbreak in South Korea in 2010.
In this study, we have described the clinical characteristics of vaccine-modified measles to assess the performance of an expanded case definition in a school outbreak that occurred in 2010. The sensitivity, specificity, and the positive and negative predictive values were evaluated. Among 74 cases of vaccine-modified measles, 47 (64%) met the original case definition. Fever and rash were ob...
متن کاملDetection and titration of measles virus antibody by hemagglutination inhibition and by dot immunobinding.
Measles continues to be a major disease of both human and nonhuman primates. The dot immunobinding assay, a modified enzyme immunoassay, permits the detection of measles virus antibody in the nonlaboratory setting with either serum or whole blood collected on filter paper.
متن کاملMeasles hepatitis in a vaccinated liver transplant recipient: case report and review of literature
Measles infection, postliver transplant, may lead to a fatal graft loss. Individuals who have been previously exposed to the measles antigen may have a modified disease presentation. Although vaccination may not provide solid immunity, it ameliorates the severity of the disease.
متن کامل